I'm doing that now. It's definitely different. You can't count on having a reasonable amount iron near you start, so production of things ends up more spread out, and there's a lot more schlepping.
Though I did start building some truck depots with factory carts bring some of my more far flung things like modular frames back to the HUB. But starting with a normal SAM node just right there, or having uranium in what would normally be a cluster of iron makes things interesting.